Super-resolution microscopy applications
We can now image cells at the highest resolution, understand molecular interactions and dynamics and study the fundamentals of biology through single-molecule fluorescence.
Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions.
Extracellular Vesicles Hub
Extracellular vesicles (EVs) play key roles in cell-to-cell communication.
ONI joins the fight against COVID-19
ONI joined the global effort to research and develop diagnostics to tackle the COVID-19 pandemic.
Visualizing Extracellular Vesicles
Super-resolution imaging can be used to study fine morphological details and precise localization of EV-associated proteins.
Until recently, due to their size and design, the majority of super-resolution microscopes have not been able to support research in enclosed, ventilated biosafety cabinets. But things are changing.
Tracking Extracellular Vesicles
Visualize and track EVs in solution or within cells to understand their behaviour.
Viral Particle Imaging
Viral particles vary greatly in size, but are typically below the resolution limit of conventional light microscopy. Recently, super-resolution techniques have been employed to study their mechanistic and functional characteristics at a single-molecule level.
Host Pathogen Interactions
By helping researchers to unravel new, dynamic information about virus particles, super-resolution micoscopy enables breakthroughs in the understanding of viral pathogens and in finding new targets to treat viral infection.
Tracking Single Molecules and Vesicles in cells
The Nanoimager can track single molecules and vesicles in both bacterial and eukaryotic cells with super-resolution microscopy.
Protein Complex Assembly
Intensity measurements, super-resolution and multi-color labeling for characterizing protein complexes and their assembly.
Quantitative Cellular Imaging
Gain detailed understanding of cellular features through multi-color super-resolution microscopy with advanced data analysis including colocalization and clustering.
Molecular Mechanisms and Interactions
Using smFRET to understand molecular interactions and dynamics, including enzymes and substrates, protein aggregates in neurodegeneration and other protein-protein interactions.