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Super-resolution microscopy applications

We can now image cells at the highest resolution, understand molecular interactions and dynamics and study the fundamentals of biology through single-molecule fluorescence.

Applications Hub

Pathogens Hub

Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions.

Extracellular Vesicles Hub

Extracellular vesicles (EVs) play key roles in cell-to-cell communication.

Neuroscience Hub

Understanding brain structure and function at a single-molecule level is key for understanding the molecular mechanisms.

Case Studies

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ONI joins the fight against COVID-19

ONI joined the global effort to research and develop diagnostics to tackle the COVID-19 pandemic.

  • dSTORM
  • Single-Particle Tracking
  • smFRET
  • Virology

Visualizing Extracellular Vesicles

Super-resolution imaging can be used to study fine morphological details and precise localization of EV-associated proteins.

  • dSTORM
  • Extracellular vesicles

Tracking Viral Particles

Understanding and quantifying viral particle behavior.

  • Single-Particle Tracking
  • Immuno-oncology
  • Virology

Biosafety Cabinets

Until recently, due to their size and design, the majority of super-resolution microscopes have not been able to support research in enclosed, ventilated biosafety cabinets. But things are changing.

  • Bacteria
  • Cell phenotyping
  • Immuno-oncology

Tracking Extracellular Vesicles

Visualize and track EVs in solution or within cells to understand their behaviour.

  • Single-Particle Tracking
  • Extracellular vesicles

Viral Particle Imaging

Viral particles vary greatly in size, but are typically below the resolution limit of conventional light microscopy. Recently, super-resolution techniques have been employed to study their mechanistic and functional characteristics at a single-molecule level.

  • dSTORM
  • Virology

Host Pathogen Interactions

By helping researchers to unravel new, dynamic information about virus particles, super-resolution micoscopy enables breakthroughs in the understanding of viral pathogens and in finding new targets to treat viral infection.

  • dSTORM
  • Single-Particle Tracking
  • Bacteria

Tracking Single Molecules and Vesicles in cells

The Nanoimager can track single molecules and vesicles in both bacterial and eukaryotic cells with super-resolution microscopy.

  • Single-Particle Tracking
  • Extracellular vesicles

Protein Complex Assembly

Intensity measurements, super-resolution and multi-color labeling for characterizing protein complexes and their assembly.

  • smFRET
  • Bacteria
  • Cell phenotyping

Quantitative Cellular Imaging

Gain detailed understanding of cellular features through multi-color super-resolution microscopy with advanced data analysis including colocalization and clustering.

  • dSTORM
  • Cell phenotyping

Molecular Mechanisms and Interactions

Using smFRET to understand molecular interactions and dynamics, including enzymes and substrates, protein aggregates in neurodegeneration and other protein-protein interactions.

  • smFRET

DNA Conformational Changes

A dynamic, real-time nanoscale ruler, now a general tool for characterizing molecular interactions and structure with Alternating Laser Excitation (ALEX) support.

  • smFRET

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