Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions.
Extracellular vesicles (EVs) play key roles in cell-to-cell communication.
Understanding brain structure and function at a single-molecule level is key for understanding the molecular mechanisms.
ONI joined the global effort to research and develop diagnostics to tackle the COVID-19 pandemic.
Super-resolution imaging can be used to study fine morphological details and precise localization of EV-associated proteins.
Understanding and quantifying viral particle behavior.
Until recently, due to their size and design, the majority of super-resolution microscopes have not been able to support research in enclosed, ventilated biosafety cabinets. But things are changing.
Visualize and track EVs in solution or within cells to understand their behaviour.
Viral particles vary greatly in size, but are typically below the resolution limit of conventional light microscopy. Recently, super-resolution techniques have been employed to study their mechanistic and functional characteristics at a single-molecule level.
By helping researchers to unravel new, dynamic information about virus particles, super-resolution micoscopy enables breakthroughs in the understanding of viral pathogens and in finding new targets to treat viral infection.
The Nanoimager can track single molecules and vesicles in both bacterial and eukaryotic cells with super-resolution microscopy.
Intensity measurements, super-resolution and multi-color labeling for characterizing protein complexes and their assembly.
Gain detailed understanding of cellular features through multi-color super-resolution microscopy with advanced data analysis including colocalization and clustering.
Using smFRET to understand molecular interactions and dynamics, including enzymes and substrates, protein aggregates in neurodegeneration and other protein-protein interactions.
A dynamic, real-time nanoscale ruler, now a general tool for characterizing molecular interactions and structure with Alternating Laser Excitation (ALEX) support.
