Super-resolution microscopy applications

The next generation of super-resolution microscope reveals biology in a new light. We can now image cells at the highest resolution, understand molecular interactions and dynamics and study the fundamentals of biology through single-molecule fluorescence.

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Extracellular Vesicles Hub

Extracellular vesicles (EVs) play key roles in cell-to-cell communication. EVs can cross biological barriers (such as the blood-brain barrier) and get internalized into the cell with a high degree of specificity.

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Pathogens Hub

Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions. Super-resolution microscopy helps find more efficient ways of diagnosing, treating and preventing them.

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Neuroscience Hub

Understanding brain structure and function at a single-molecule level is key for understanding the molecular mechanisms underlying neurodegenerative disorders and improve early disease diagnosis.

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Application Case Studies

Biosafety Cabinets

Until recently, due to their size and design, the majority of super-resolution microscopes have not been able to support research in enclosed, ventilated biosafety cabinets. But things are changing.

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Tracking Extracellular Vesicles

Visualize and track EVs in solution or within cells to understand their behaviour.

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Tracking Viral Particles

Understanding and quantifying viral particle behavior.

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Viral Particle Imaging

Viral particles vary greatly in size, but are typically below the resolution limit of conventional light microscopy. Recently, super-resolution techniques have been employed to study their mechanistic and functional characteristics at a single-molecule level.

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Host Pathogen Interactions

By helping researchers to unravel new, dynamic information about virus particles, super-resolution micoscopy enables breakthroughs in the understanding of viral pathogens and in finding new targets to treat viral infection.

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Visualizing Extracellular Vesicles

Super-resolution imaging can be used to study fine morphological details and precise localization of EV-associated proteins.

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Tracking Single Molecules and Vesicles in cells

The Nanoimager can track single molecules and vesicles in both bacterial and eukaryotic cells with super-resolution microscopy.

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Quantitative Cellular Imaging

Gain detailed understanding of cellular features through multi-color super-resolution microscopy with advanced data analysis including colocalization and clustering.

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Protein Complex Assembly

Intensity measurements, super-resolution and multi-color labeling for characterizing protein complexes and their assembly.

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Molecular Mechanisms and Interactions

Using smFRET to understand molecular interactions and dynamics, including enzymes and substrates, protein aggregates in neurodegeneration and other protein-protein interactions.

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DNA Conformational Changes

A dynamic, real-time nanoscale ruler, now a general tool for characterizing molecular interactions and structure with Alternating Laser Excitation (ALEX) support.

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Epigenetic Mapping

Imaging specific target sites on DNA at the single-molecule level: a simple tool for characterizing the distribution of epigentic sites.

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DNA-PAINT shows sub-20 nm resolution

DNA-PAINT provides easy localization-based super-resolution with nanorulers from GATTAquant GmbH.

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How to size, track and characterize EVs

Download our EV Application Note explaining how researchers can size, track and characterize extracellular vesicles in solution or in live cells.

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