ONI Resources

Extracellular Vesicles

Extracellular vesicles

  • Harness the power of single-molecule detection

    Exosomes and super-resolution microscopy

    Dr. Ryan McNamara demonstrates the role of tetraspanin proteins in tracking exosome maturation inside of the cell and the relevance of super-resolution microscopy to visualize and characterize extracellular vesicles to understand their relevance in research.

  • Tracking EVs in solution and in cells

    Developing novel drug delivery systems: following EV uptake in live cells

    Learn how the Nanoimager allows visualization, quantification and tracking of EVs at a single-molecule level, in solution and in live cells.

  • Harness the power of single-molecule detection

    Harness the power of single-molecule detection, at your finger tips

    Dr. Siobhan King highlights applications that can be performed on the Nanoimager including detecting and visualizing extracellular vesicles as well as imaging and tracking viral particles.

  • EV biomarkers: characterizing EV composition and cargo at a single-molecule level

    Learn how the Nanoimager platform allows visualization and quantification of extracellular vesicles at a single-molecule level.

    Download Now

  • How to size, track and characterize EVs

    We've compiled our latest data in a simple application note to demonstrate how researchers can size, track and characterize extracellular vesicles in solution or in live cells.

    Download Now

  • EV imaging guide

    This guide focuses on recent progress in fluorescent super-resolution imaging and characterization of extracellular vesicles.

    Download PDF

Immunology

Immuno-oncology

  • Advancing immuno-oncology

    Advancing immuno-oncology: discovery, delivery and diagnosis with super-resolution microscopy

    Dr. Michael Senior discusses exciting opportunities for accelerating the development pipeline and how single-molecule microscopy can deliver effective personalized immunotherapy.

Neuroscience

Neuroscience

  • Neurons: revealing synapse architecture at a single-molecule level

    Learn how the Nanoimager platform supports super-resolution imaging of cultured neuronal cells and the precise localization of different synaptic proteins.

    Download Now

  • Modeling disease through single-molecule in vivo imaging in brain tissues

    Learn how the Nanoimager platform supports imaging of brain tissue at high sensitivity and the visualization of synaptic proteins at a single-molecule level.

    Download Now

  • Neuroscience PALM array tomography

    Learn how the Nanoimager platform allows imaging of brain tissue at high-sensitivity and the visualization of individual synaptic proteins at high-resolution.

    Download Now

Virus research and Vaccine development

Virus research & vaccine development

  • Learn about viral particles

    Download our viral particle application note which includes case studies on sizing, tracking and quantification of viral particles.

    Download Now

  • Visualizing viral particles at a single molecule level

    Learn how the Nanoimager platform allows visualization and quantification of viral particles at a single molecule level.

    Download Now

Cell phenotypic

Cell phenotyping

  • A journey through the cell video

    A journey through the cell: Unveiling life at a single-molecule level

    Dr. Mark Harmon highlights how to visualize structures from cell membrane to nucleus in unprecedented detail. With its small but mighty design, the Nanoimager delivers the ability to see, count and track single molecules from the convenience of your benchtop.

  • Capruting organelle contact sites

    Capturing organelle contact sites assembly to unveil disease onset in live cells

    Learn how the Nanoimager allows real-time visualization and quantification of cellular processes at a single-molecule level, in live cells.

Bacterial research

Bacterial research

  • Capruting organelle contact sites

    Developing new antibiotics: from target identification to mechanism validation

    Learn how the Nanoimager provides a multiplex solution for novel antibiotic development.

    Download Now

  • Characterizing bacterial infection in epithelial cells

    Characterizing bacterial infection in epithelial cells at a single-molecule level

    Learn how the Nanoimager enables visualization and quantification of bacterial infection and host-pathogen interactions at a single-molecule level.

    Download Now

Other ONI documents

Microscopy

  • Nanoimager technical specifications

    Download the full Nanoimager technical specifications as a PDF.

    Download PDF

  • Popular fluorophores for PALM imaging

    We've put together a one page, printable PDF table to help you compare the most popular fluorophores used for PALM imaging, which include photoactivatable, photoconvertible and photoswitchable fluorescent proteins, as well as synthetic dyes.

    Download Now

  • Which super-resolution technique is right for you?

    We've put together a one page, printable PDF to help you choose between the Nanoimager's key super-resolution microscopy techniques. It covers core techniques including dSTORM, PALM, SPT and smFRET.

    Download PDF

  • Beginner's guide to STORM buffers

    When preparing a sample for STORM microscopy it is also crucial to select an appropriate buffer solution, which will efficiently regulate blinking behavior and help achieve high quality super-resolution images. Here is a brief guide to STORM buffer components and how they can affect sample imaging.

    Read More

  • 9 tips to optimize your immunofluorescence staining

    We have put together some tips to help you optimize your immunofluorescence staining protocol and increase the signal-to-noise ratio in your samples.

    Read More

More Information?

Our team of scientists are waiting to help with your questions