<p><strong>Upcoming Webinar:</strong> DNA-PAINT for Molecular Imaging <strong><span style="text-decoration: underline;">register</span></strong><span style="text-decoration: underline;"><strong>></strong></span></p>

Upcoming Webinar: DNA-PAINT for Molecular Imaging register>

The FASEB Journal, November 2024

High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)

Hiroaki Fukumoto, Tzu-Huei Kao, Chin-Yin Tai, Ming-Kuei Jang, Masaomi Miyamoto

Tags
  • Neuroscience
  • dSTORM

Cell Death & Disease, June 2024

Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis

Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma, Jinying Xu, Yingying Fan, Yuewen Chen & Yu Chen

Tags
  • Neuroscience
  • dSTORM

Neuron, July 2023

Synaptic oligomeric tau in Alzheimer’s disease — Apotential culprit in the spread of tau pathologythrough the brain

Martı´ Colom-Cadena, Caitlin Davies, So` nia Sirisi, ..., Mathew H. Horrocks, Alberto Lleo´ , Tara L. Spires-Jones

Tags
  • Neuroscience
  • dSTORM

EMBO J, September 2023

Loss of TDP-43 oligomerization or RNA bindingelicits distinct aggregation patterns

Pérez-Berlanga M, Wiersma VI, Zbinden A, De Vos L, Wagner U, Foglieni C, Mallona I, Betz KM, Cléry A, Weber J, Guo Z, Rigort R, de Rossi P, Manglunia R, Tantardini E, Sahadevan S, Stach O, Hruska-Plochan M, Allain FH, Paganetti P, Polymenidou M.

Tags
  • Neuroscience
  • Live imaging

Nature Machine Intelligence, August 2023

Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models

Karishma D’Sa, James R. Evans, Gurvir S. Virdi, Giulia Vecchi, Alexander Adam, Ottavia Bertolli, James Fleming, Hojong Chang, Craig Leighton, Mathew H. Horrocks, Dilan Athauda, Minee L. Choi & Sonia Gandhi

Tags
  • Neuroscience
  • dSTORM

medRxiv , March 2023

Synaptic oligomeric tau in Alzheimer’s disease – a potential culprit in the spread of tau pathology through the brain

Martí Colom-Cadena, Caitlin Davies, Sònia Sirisi, Ji-Eun Lee, Elizabeth Simzer, Makis Tzioras, Marta Querol-Vilaseca, Érika Sánchez-Aced, Ya Yin Chang, Kris Holt, Robert McGeachan, Jamie Rose, Jane Tulloch, Lewis Wilkins, Colin Smith, Teodora Andrian, Olivia Belbin, Sílvia Pujals, Mathew H. Horrocks, Alberto Lleó, Tara Spires-Jones

Tags
  • Neuroscience
  • PAINT

Nature Communications, January 2023

mGluR5 is transiently confined in perisynaptic nanodomains to shape synaptic function

Nicky Scheefhals, Manon Westra & Harold D. MacGillavry

Tags
  • Neuroscience
  • SMLM

BioRxiv, October 2022

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s
2 disease in midbrain dopaminergic neurons

Gurvir S Virdi, Minee L Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Anna I Wernick, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Tilo Kunath, Mathew H Horrocks, Andrey Y Abramov, Rickie Patani, Sonia Gandhi

Tags
  • Neuroscience
  • SMLM

PLOS Genetic, February 2022

FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function

Emily L. Starke,Keelan Zius,Scott A. Barbee

Tags
  • Neuroscience

Current Biology, May 2022

Myotubularin-related phosphatase 5 is a critical determinant of autophagy in neurons

ason P. Chua Karan Bedi Michelle T. Paulsen Mats Ljungman Elizabeth M.H. Tank Erin S. Kim Jonathon P. McBride Jennifer M. Colón-Mercado Michael E. Ward Lois S. Weisman Sami J. Barmada

Tags
  • Neuroscience
  • dSTORM

bioRxiv, April 2022

RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

M McMillan, N Gomez, M Bekier, X Li, R Miguez, EM Tank, SJ Barmada

Tags
  • Neuroscience

bioRxiv, May 2022

TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies

Manuela Pérez-Berlanga, Vera I. Wiersma, Aurélie Zbinden, Laura De Vos, Ulrich Wagner, Chiara Foglieni, Izaskun Mallona, Katharina M. Betz, Antoine Cléry, Julien Weber, Zhongning Guo, Ruben Rigort, Pierre de Rossi, Ruchi Manglunia, Elena Tantardini, Sonu Sahadevan, Oliver Stach, Marian Hruska-Plochan, Frederic H.-T. Allain, Paolo Paganetti, Magdalini Polymenidou

Tags
  • Neuroscience
  • Widefield