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12 of 323 results

BiorXiv, April 2024

Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimer’s Disease Brain Tissue

Adriana N. Santiago-Ruiz, Siewert Hugelier, Charles R. Bond, Edward B. Lee, Melike Lakadamyali

Tags
  • Signaling
  • PAINT

BiorXiv, April 2024

Elucidation of the molecular mechanism of the breakage-fusion-bridge (BFB) cycle using a CRISPR-dCas9 cellular model

Manrose Singh, Kaitlin Raseley, Alexis M. Perez, Danny MacKenzie, Settapong T Kosiyatrakul, Sanket Desai, Noelle Batista, Navjot Guru, Katherine K. Loomba, Heba Z. Abid, Yilin Wang, Lars Udo-Bellner, Randy F. Stout, Carl L. Schildkraut, Ming Xiao, Dong Zhang

Tags
  • Nanotechnology
  • dSTORM

BiorXiv, April 2024

Single molecule tracking reveals nanodomains in biomolecular condensates

Guoming Gao, Emily R. Sumrall, Nils G. Walter

Tags
  • Single-Particle Tracking

Extracell Vesicles Circ Nucleic Acids , March 2024

Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles

Mitchell MI, Ben-Dov IZ, Liu C, Wang T, Hazan RB, Bauer TL, Zakrzewski J, Donnelly K, Chow K, Ma J, Loudig O.

Tags
  • Extracellular vesicles
  • dSTORM

PNAS Nexus, March 2024

Structural constraints of pyocin S2 import through the ferripyoverdine receptor FpvAI

Goult JD, Van DCL, Taylor YV, Inns PG, Kaminska R, Vesely M, Kleanthous C, Paci E

Tags
  • Bacteria

Nature Microbiology, March 2024

Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon

Frédéric Lauber, Justin C. Deme, Xiaolong Liu, Andreas Kjær, Helen L. Miller, Felicity Alcock, Susan M. Lea & Ben C. Berks

Tags
  • Bacteria
  • HILO

BiorXiv, March 2024

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate

Isabella M Valentino, Jeniffer G Llivicota-Guaman, Thuy P Dao, Erin O Mulvey, Andrew M Lehman, Sarasi K. K. Galagedera, Erica L Mallon, Carlos A Castañeda, Daniel A Kraut

Tags
  • Widefield

Nature Communication, March 2024

Focal adhesions contain three specialized actin nanoscale layers

Kumari R, Ven K, Chastney M, Kokate SB, Peränen J, Aaron J, Kogan K, Almeida-Souza L, Kremneva E, Poincloux R, Chew TL, Gunning PW, Ivaska J, Lappalainen P.

Tags
  • Biosensing
  • Live Imaging

Nature Biomedical Engineering, March 2024

PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes

Ruiyang Pang, Weihao Sun, Yingyun Yang, Dahan Wen, Feng Lin, Dingding Wang, Kailong Li, Ning Zhang, Junbo Liang, Chunyang Xiong & Yuying Liu

Tags
  • Immuno-oncology
  • dSTORM

BiorXiv, March 2024

Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition

Charles Bond, Siewert Hugelier, Jiazheng Xing, Elena M. Sorokina, Melike Lakadamyali

Tags
  • PAINT

Nature communications, March 2024

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

R. Sumanth Iyer, Sarah R. Needham, Ioannis Galdadas, Benjamin M. Davis, Selene K. Roberts, Rico C. H. Man, Laura C. Zanetti-Domingues, David T. Clarke, Gilbert O. Fruhwirth, Peter J. Parker, Daniel J. Rolfe, Francesco L. Gervasio & Marisa L. Martin-Fernandez

Molecular Cancer , March 2024

Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

Yufei Wang, Alicia Buck, Brandon Piel, Luann Zerefa, Nithyassree Murugan, Christian D. Coherd, Andras G. Miklosi, Haraman Johal, Ricardo Nunes Bastos, Kun Huang, Miriam Ficial, Yasmin Nabil Laimon, Sabina Signoretti, Zhou Zhong, Song-My Hoang, Gabriella M. Kastrunes, Marion Grimaud, Atef Fayed, Hsien-Chi Yuan, Quang-De Nguyen, Tran Thai, Elena V. Ivanova, Cloud P. Paweletz, Ming-Ru Wu, …Wayne A. Marasco

Tags
  • Immuno-oncology
  • dSTORM