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Aplo Flow
Automated sample preparation
Aplo Flow
Super-resolution simplified
Aplo Flow revolutionizes super-resolution microscopy by combining application-specific sample preparation with fully automated fluidic control. By integrating automated fluidics directly into the Aplo Platform, it delivers a reliable, reproducible, end-to-end workflow that minimizes hands-on time while improving experimental consistency.
From advanced imaging applications such as DNA-PAINT and exchange imaging to automated workflows for lipid nanoparticle (LNP) characterization and extracellular vesicle (EV) profiling, Aplo Flow enables researchers to streamline complex single-particle experiments within one unified system.
Enhanced throughput and modular design
Aplo Flow increases speed and scalability, preparing up to 16 samples in 4.5 hours while reducing hands-on time by up to 85% per sample. Supporting DNA-PAINT, automated sample preparation, and extracellular vesicle characterization, Aplo Flow standardizes nanoparticle sample preparation through programmable fluidics and integrated analysis, enabling seamless sample-to-answer single-particle workflows for research and biopharma development.
One system, two modes of operation
Automated sample preparation
Streamline your workflow by automating the preparation of multiple samples in parallel on the deck of the Aplo Flow system. Start imaging immediately after a preparation, or store samples at 4°C for imaging the next day. Aplo Flow is designed to speed up your time to results and maintain assay flexibility while simultaneously reducing hands on time by up to 85% per sample.
Available for Aplo Scope and Nanoimager today.
Fluidics microscopy
Aplo Flow integrates programmable fluidics with the Aplo Scope to automate complex fluidic assays on-chip. Capable of supporting workflows such as DNA-PAINT, live cell assays, and particle uptake, Aplo Flow enables controlled reagent delivery under a unified ecosystem. By linking fluidics, imaging, and analysis, the Aplo Platform delivers a streamlined sample-to-answer workflow for research and biopharma applications.
Key features
Higher throughput
Up to 16 samples ready to image in 4.5 hours
Less hands-on time
85% less hands-on time per sample
Faster sample to answer
350% less time from sample to answer
Configurable workflow design
Modular architecture enables advanced flexibility
Discover
Aplo Flow
Aplo Flow
EV Profiler 2
Reagent kit for visualization and phenotyping of extracellular vesicles
Pipettor
Provides precise, automated fluid handling, enhancing efficiency and reproducibility
Chip holder
Custom ONI fluidics chip holder (four positions)
Dual tip rack storage
Enough tips for uninterrupted pipetting for up to 12 samples
Waste capture station
Collects used tips and sample waste for disposal
Custom fluidics pass-through
Fluidic tether pass through for sequential reagent perfusion
Light safe windows
Helps to block harmful light from damaging samples
Custom reagent holder
Workflow specific labware positions for intuitive deck loading
Get a closer look
Explore
Providing tools to make super-resolution microscopy more accessible.
FAQs
How does Aplo Flow improve workflow efficiency?
Aplo Flow enhances workflow efficiency by fully automating sample preparation for any of ONIs custom reagent kits. With less than 30 minutes of hands on time, even a novice scientist can prepare 12 samples with high reliability and consistency. Then, instead of spending hours preparing samples by hand, Aplo Flow users are free to image other samples, analyze yesterday’s dataset, or plan their next experiment. More answers in less time – the true meaning of efficiency.
How many samples can Alpo flow process per run?
Users can choose to process anywhere from 1 sample up to 12 in a single run (3x chips with 4x lanes on each), indicating custom experimental conditions for each lane before starting the experiment.
How adaptable is Aplo Flow to different research needs?
Aplo Flow’s modular experimental design provides versatility with 35 unique configurations possible per sample, catering to various research needs and protocols, ensuring adaptability and scalability for diverse scientific applications.
What support and resources are available for users of Aplo Flow?
Users of Aplo Flow have access to comprehensive support and resources, including training materials, technical assistance, and software updates. This ensures that researchers can maximize the capabilities of Aplo Flow and achieve their scientific goals efficiently and effectively.