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12 of 270 results

BiorXiv, March 2024

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate

Isabella M Valentino, Jeniffer G Llivicota-Guaman, Thuy P Dao, Erin O Mulvey, Andrew M Lehman, Sarasi K. K. Galagedera, Erica L Mallon, Carlos A Castañeda, Daniel A Kraut

Tags
  • Widefield

BiorXiv, March 2024

Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition

Charles Bond, Siewert Hugelier, Jiazheng Xing, Elena M. Sorokina, Melike Lakadamyali

Tags
  • PAINT

Nature communications, March 2024

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

R. Sumanth Iyer, Sarah R. Needham, Ioannis Galdadas, Benjamin M. Davis, Selene K. Roberts, Rico C. H. Man, Laura C. Zanetti-Domingues, David T. Clarke, Gilbert O. Fruhwirth, Peter J. Parker, Daniel J. Rolfe, Francesco L. Gervasio & Marisa L. Martin-Fernandez

Scientific reports, March 2024

Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity

Nathaniel Safren, Thuy P. Dao, Harihar Milaganur Mohan, Camellia Huang, Bryce Trotter, Carlos A. Castañeda, Henry Paulson, Sami Barmada & Lisa M. Sharkey

Tags
  • Widefield

BiorXiv, March 2024

Scalable Isolation of Surface-Engineered Extracellular Vesicles and Separation of Free Proteins via Tangential Flow Filtration and Size Exclusion Chromatography (TFF-SEC)

Yuki Kawai-Harada, Vasudha Nimmagadda, Masako Harada

Tags
  • Extracellular vesicles
  • dSTORM

BiorXiv, March 2024

Spatial targeting of the prostaglandin receptor EP2 to very early endosomes co-ordinates PGE2-mediated cAMP signaling in decidualizing human endometrium

Paul J. Brighton, Abigail R. Walker, Oliver Mann, Chow-Seng Kong, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens, Aylin C. Hanyaloglu

Tags
  • Signaling
  • Widefield

Nature Communications, March 2024

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

Zhenzhen Wang, Shiqi Hu, Kristen D. Popowski, Shuo Liu, Dashuai Zhu, Xuan Mei, Junlang Li, Yilan Hu, Phuong-Uyen C. Dinh, Xiaojie Wang & Ke Cheng

Tags
  • Virology
  • Widefield

BiorXiv, March 2024

Reconfigurable multi-component nanostructures built from DNA origami voxels

Minh Tri Luu, Jonathan F. Berengut, Jasleen Kaur Daljit Singh, Kanako Coffi Dit Glieze, Matthew Turner, Karuna Skipper, Sreelakshmi Meppat, Hannah Fowler, William Close, Jonathan P.K. Doye, Ali Abbas, Shelley F.J. Wickham

Tags
  • Nanotechnology
  • PAINT

EMBO Mol Med, March 2024

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes

Han G, Zhang Y, Zhong L, Wang B, Qiu S, Song J, Lin C, Zou F, Wu J, Yu H, Liang C, Wen K, Seow Y, Yin H.

Tags
  • Extracellular vesicles
  • dSTORM

Nature communications, March 2024

Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Rosa Antón, Miguel Á. Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J. Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M. Vera & Javier Oroz

Tags
  • Signaling
  • TIRF

BiorXiv, February 2024

GLP1 receptor agonism ameliorates Parkinson’s disease through modulation of neuronal insulin signalling and glial suppression

Dilan Athauda, James R Evans, Laura Mahoney-Sanchez, Gurvir S Virdi, Patricia Lopez-Garcia, Anna Wernick, Aaron Wagen, Karishma D’Sa, Joanne Lachica, Stephanie Strohbuecker, Giulia Vecchi, Craig Leighton, Rebecca S. Saleeb, Judi O’Shaughnessy, Christina E. Toomey, Nirosen Vijiaratnam, Christine Girges, Yazhou Li, Maja Mustapic, Khalida Ismail, Melanie Davies, Dimitrios Kapogiannis, Minee L Choi, Mina Ryten, Mathew H. Horrocks, Nigel Greig, Thomas Foltynie, Sonia Gandhi

Tags
  • Widefield

Journal of Extracellular Biology, February 2024

Profile of matrix-entrapped extracellular vesicles of microenvironmental and infiltrating cell origin in decellularized colorectal cancer and adjacent mucosa

Sarah Tassinari, Edoardo D'Angelo, Federico Caicci, Cristina Grange, Jacopo Burrello, Matteo Fassan, Alessia Brossa, Riccardo Quoc Bao, Gaya Spolverato, Marco Agostini, Federica Collino, Benedetta Bussolati

Tags
  • Extracellular vesicles
  • dSTORM